Analysis of the Monoclonal Antibody Pembrolizumab for Treating Cancer

ByShaun Snapp

Executive Summary

  • Monoclonal antibodies are one of the major categories of immunotherapy treatments.
  • One of the most popular is Pembrolizumab.

Introduction

Monoclonal antibodies designed to treat cancer are manufactured to kill cancer cells.

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Understanding Monoclonals

This graphic from the National Institutes of Health shows how monoclonal designed to fight covid interferes with the spike protein.

The NIH, of course, left out that the mRNA vaccines lead to large numbers of spike proteins that are created — due to the instructions from the vaccines — for years, causing all manner of damage to the body, specifically to the immune system. 

The NIH and the rest of the medical establishment will not communicate accurate information to the public if it reflects poorly on the medical establishment.

Targeted (Monoclonal) Antibodies

Some excellent explanations of immunotherapy are found in the quotations from Cancer Research.

Targeted antibodies are proteins produced by the immune system that can be customized to target specific markers (known as antigens) on cancer cells, in order to disrupt cancerous activity, especially unrestrained growth. Some targeted antibody-based immunotherapies, known as antibody-drug conjugates (ADCs), are equipped with anti-cancer drugs that they can deliver to tumors. Others, called bi-specific T cell-engaging antibodies (BiTEs), bind both cancer cells and T cells in order to help the immune system respond more quickly and effectively. All targeted antibody therapies are currently based on monoclonal antibodies (clones of a parent bonding to the same marker(s)).

This is a definition of monoclonal antibodies from the National Cancer Institute.

A type of protein that is made in the laboratory and can bind to certain targets in the body, such as antigens on the surface of cancer cells. There are many kinds of monoclonal antibodies, and each monoclonal antibody is made so that it binds to only one antigen. Monoclonal antibodies are being used in the diagnosis and treatment of many diseases, including some types of cancer. They can be used alone or to carry drugs, toxins, or radioactive substances directly to cancer cells.

This video does an excellent job of explaining how monoclonal antibodies work. 

This video is from the National Cancer Institute on monoclonal antibodies.

No Use of Immunotherapy for Those With Autoimmune Disorders?

This quote explains why immunotherapy is not used for cancer patients with autoimmune disorders.

This quote is from the website of the Cancer Center.

Sometimes, the immune system malfunctions. When it mistakenly identifies the body’s normal cells as a threat, the result is an autoimmune disorder, like rheumatoid arthritis, lupus or Crohn’s disease.

To elaborate on this point, immune systems are far more likely to malfunction when the individual is under chronic stress. We know this because chronic stress leads to inflammation — as I cover in the article The Relationship Between Inflammation and Cancer.