The Mechanisms of How Anti Parasitic Drugs Work to Mitigate Cancer

Executive Summary

• Ivermectin and other anti-parasitic drugs work to reduce cancer through multiple mechanisms of action.

Article Summary

This article covers the history of the effectiveness of anti parasitic drugs (like Ivermectin and Fenbendazole) versus cancer and then the mechanisms by which Ivermectin works against cancer.

Introduction

In a previous article titled How Ivermectin Is Useful for Treating Cancer we covered the evidence for the benefits of Ivermectin for cancer. But the question of the mechanism for how both Ivermectin and other anti parasitic drugs work against cancer. The first article was more directed towards the layman audience, those with cancer or friends or family who have cancer. This article must get more technical as the mechanisms are complicated and get into detailed biological explanations.

The Relationship Between Anti Parasitic Drugs and Cancer Prevention and Treatment

There is some relationship between anti parasitic drugs and cancer prevention and treatment, which researchers have not explored sufficiently.

The following quotations from the website Parawellness are illustrative of this relationship.

In practical terms, doctors believe that most people do not really have a parasite problem. This is fostered by the large number of stool parasite tests that are reported negative by conventional labs. As a medical lab technician in my earlier years I can tell you that the responsibility to examine specimens for parasites under the microscope is relegated to a low time and effort priority given all the other testing that labs must accomplish in the course of a day. This is really unfortunate because parasites are present in most people when the specimens are prepared properly and adequate time is spent examining multiple microscope slides thoroughly. Few doctors give much attention to the possibility of parasitic infection when it comes to initiation or continuation of cancers. A partial reason for this is that doctors and patients are under a false belief that our public health and sanitation is effective enough to prevent parasite problems.

This quote proposes that parasites are a blind spot for modern medicine.

Enumerating The Mechanisms Whereby Ivermectin Addresses Cancer

These include the following items but are not limited to the following items.

Mechanism #1: By Killing Parasites

Now we get to Ivermectin’s first and most apparent mechanism: killing or reducing parasite load.

Diagnostic medical parasitology is the branch of medical science that examines body fluids and tissues for the presence of parasites. I have been involved in this since 1966 when I served as an Air Force microbiology technician in Viet Nam. After medical school and a residency in family medicine I continued my career as a parsitologist by setting up and running labs in practices where I worked. Now that I am partially retired, I specialize in parasite exams for people who want to know what is really happening to them.

There is a potential financial bias here, as this person sells parasite test kits. However, this author, Dr. Raphael d’Angelo, may have begun offering this because this research concludes that they are essential as people should know their parasitical load.

• However, this is not a far-fetched proposal, and there is a relationship between antiparasitics and cancer improvement — therefore, this is a supported contention.
• Secondly, these kits sell for $326. So this is not some mega-industry with enormous conflicts of interest as with the pharmaceutical industry, cancer-treating medical doctors, cancer-treating hospitals, or the American Cancer Society (which advises against nutrition supplements as we cover in the article The American Cancer Society’s Skepticism of Nutrition Supplements), etc…

Mechanism #2: Attacking the Mitochondria in Cancer Cells

Ivermectin attacks mitochondria in cancer cells, causing those cells to die.

Mechanism #3: Improving Apoptosis in Cancer Cells

It improves the mechanism of programmed cell death (apoptosis) overall. The article How Ivermectin Improves Cancer Prevention and Treatment Through Apoptosis covers this.

Mechanism #4: Reducing Drug Resistance

It reduces the drug resistance to chemotherapy drugs. This is explained in the article How Ivermectin Helps Reduce Chemotherapy Drug Resistance in Cancer Cells.

Mechanism #5: Immunomodulation

It improves the immune response and, therefore, the entire immune system, which allows the immune system to repair cellular damage — which is how cancer begins. The article What is Immunomodulation and What Are Immunomodulators? explains more about immunomodulators. How Ivermectin works as an immunomodulator is explained in the article How Ivermectin Improves the Immune Response by Acting as an Immunomodulator. 

Mechanism #6: Reducing Chronic Inflammation

It reduces chronic inflammation (the primary determinant in cancer development.) How Ivermectin works with chronic inflammation is explained in How Ivermectin is Effective in Stopping Inflammatory Cytokines and Cytokine Storms. This is also explained in The Role of Ivermectin and Vitamin D in Reducing General Chronic Inflammation.

• A significant feature of cancers is chronic inflammation on the part of the patient. I cover this topic in the article The Relationship Between Cancer and Inflammation.
• It has been known that chronic inflammation is strongly related to cancer development and that parasites can cause chronic inflammation.

The following is from the quote Cancer.org

In chronic inflammation, the inflammatory process may begin even if there is no injury, and it does not end when it should.

Why the inflammation continues is not always known. Chronic inflammation may be caused by infections that don’t go away, abnormal immune reactions to normal tissues, or conditions such as obesity.

Over time, chronic inflammation can cause DNA damage and lead to cancer.

Mechanism #7: Anti-Tumor Effects

Ivermectin has been shown to shrink tumors, as is covered in the article How Does Ivermectin Reduce Cancerous Tumors?

Mechanism #8: Reducing Metastasis

Ivermectin has been shown to reduce metastasis, as is covered in the article The Testing Evidence for Using Ivermectin for Treating Metastasis.

More About The C19Early Clinical Trial Comparison Website

The C19early.com website tracks clinical trials. It is the best source of information on the studies of the effectiveness based upon clinical trials of different treatments for covid. However, it is more than this - as it is a model for how clinical trials should be communicated to the public so the extraordinarily corrupt medical establishment does not control the information. And it is the website that the medical establishment would like banned from the Internet.

One of the things the C19Early website showed was that early treatment significantly impacted the outcomes against covid.

The Benefit of Early Treatment

Notice that the earlier the treatment is used, the better the outcomes. Naturally, early treatment is measured in days with a respiratory disease like COVID-19, while in months with a disease like cancer. So the timings are different, but the principle is the same. 

Even though this website does not track cancer clinical trials (unfortunately, no website does), the site holds essential observations. For one, a person's response to covid is like their response to cancer, greatly dependent upon the strength and health of their immune system.

Things like Zinc, Ivermectin, and Fenbendazole all empower the immune system and are, therefore, effective in the treatment and prevention of both COVID and cancer. 

Offering Cancer Prevention as Well as Treatment

What is better than treatment is prevention. For anyone who is concerned with cancer prevention, both a very healthy lifestyle and diet, as well as things like Ivermectin and or Fenbendazole, are things that can be taken both as a treatment and as a preventative. We cover all these topics and the supporting specifics on our subscription website. 

Impacts of Ivermectin on Cancer

The following are how Ivermectin works against cancer.

Impact #1: Inhibiting Proliferation of Tumor Cells

Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways.

The Ivermectin blocking of PAK1 proteins, aka activated kinase, is a reason for this.

The instrumentality of PAK1 in cancer growth is explained in the following quotation from the article Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations.

Impact #2: Inhibiting Metastasis

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells.

Metastasis is how cancer spreads, and I cover this in detail in the article How Does Metastasis Work in the Body?

Impact #3: Promoting Apoptosis & Pyropoptsis

ivermectin promotes programmed cancer cell death, including apoptosis, autophagy, and pyropoptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Second, IVM seems to induce mixed cell death in tumor cells, which is also a controversial issue

A significant issue with the dysfunction of cancer is that the cancerous cells refuse instructions from the immune system to commit suicide -- or what is scientifically referred to as apoptosis. I cover apoptosis in the article How Ivermectin Improves Cancer Prevention and Treatment Through Improving Apoptosis or Programmed Cell Death.

Pyropoptosis is a type of apoptosis that is caused by inflammation.

Impact #4: Promoting Autophagy

Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells.

Autophagy clears away cells and recycles them. Different things can trigger more autophagy. I cover autophagy in the article Is Autophagy Effective Against Cancer?

Impact #5: Inhibit Cancer Cell Proliferation Through Inhibiting YAP1 Activity

Lung cancer has the highest morbidity and mortality among cancers. Nishio found that IVM could significantly inhibit the proliferation of H1299 lung cancer cells by inhibiting YAP1 activity.

Conclusion

There is ample evidence that Ivermectin is helpful against many different types of cancers. It is unlikely that these are the only cancers for which Ivermectin is effective, but the studies we have found so far show that Ivermectin works to combat and prevent it. Ivermectin is an immuno-modulator, so it has beneficial effects not only for cancer -- as one of the mechanisms of how Ivermectin works is improving the immune system, which means it improves the immune system against cancer and other diseases.

Regarding the dosage and sourcing of Ivermectin, see the article On the Topic of Ivermectin Dosage and Sourcing.

Why Are Anti-Parasitic Drugs Effective Against Cancer?

To understand why this class of drugs works against cancer, see the article The Mechanism of How Anti-Parasitic Drugs Work to Mitigate Cancer.

About Our Ivermecting Testing Program and Recommended Ivermectin Source of Supply

• We performed pharmaceutical testing on Ivermectin to find a lower-cost version that also matched Merck's original Ivermectin in bioequivalence.
• You can read about the details of our Ivermectin testing in this article, Our Ivermectin Bioequivalence Testing.
• We got Summit Products to carry this version of Ivermectin, which passed our bioequivalence testing. 

Conclusion

There are multiple mechanisms by which Ivermectin prevents and treats cancer. The question of which mechanism is most dominant may not be answerable. It would require so many studies, and it would not be easy to separate and measure the mechanisms independently.

For people with cancer, the only important factors are whether Ivermectin works (it does), the side effects (which are very low), and the cost (which is also very low).

About Our Ivermecting Testing Program and Recommended Ivermectin Source of Supply

• We performed pharmaceutical testing on Ivermectin to find a lower-cost version that also matched Merck's original Ivermectin in bioequivalence.
• You can read about the details of our Ivermectin testing in this article, Our Ivermectin Bioequivalence Testing.
• We got Summit Products to carry this version of Ivermectin, which passed our bioequivalence testing.