The Testing Evidence for Using Ivermectin for Treating Lymphoma in Dogs
Executive Summary
- This article covers the evidence I could find for Ivermectin as a treatment for Lymphoma in Dogs.
Introduction
This article provides an overview covering the evidence for Ivermectin versus Lymphoma in Dogs.
In many articles on this site, such as the article How Ivermectin Is Useful for Treating Cancer we covered the evidence for the benefits of Ivermectin for cancer. However, the topic of which specific cancers Ivermectin has been proven effective is a constant source of questions.
There are a lot of quotes in this article, but I have a short one for each cancer type. The article uses the term “IVM” to mean Ivermectin.
About the Brightwork Research Treatment Database
A bit about us -- we have a subscription website that provides people with everything they need to know about using Ivermectin for several diseases. Cancer is just one of our most researched areas.
Article Indexes
- Open this link to see just one example Ivermectin article index.
- Open this link to see the full article index.
Cancer Type #3: Lymphoma in Dogs
There are few studies on the effect of Ivermection on lymphomas. There are many types of lymphoma. However, there has been a study on CML or chronic myeloid leukemia — which is related to lymphoma.
This quote is from the article Ivermectin, a Potential Anticancer Drug Derived from an Antiparasitic Drug.
Wang’s experiment found that IVM could selectively induce mitochondrial dysfunction and oxidative stress, causing chronic myeloid leukemia K562 cells to undergo increased caspase-dependent apoptosis compared with normal bone marrow cells.
This means that Ivermectin was shown to improve the ability of the immune system to kill cancerous cells in the bone marrow. This is consistent with how Ivermectin also works against other cancers.
The Mechanisms by Which Ivermectin Works Against Cancer
Confidence in Ivermectin being effective for many cancer types also comes from understanding the specific mechanisms by which Ivermectin works against cancer. I cover this topic in detail in the article By How Many Different Mechanisms Does Ivermectin Fight Cancer?
The Impact of Ivermectin on Cancer
The different ways that ivermectin impacts cancer are explained in the following items.
The Mechanisms by Which Ivermectin Works Against Cancer
Confidence in Ivermectin being effective for many cancer types also comes from understanding the specific mechanisms by which Ivermectin works against cancer. I cover this topic in detail in the article By How Many Different Mechanisms Does Ivermectin Fight Cancer?
More About The C19Early Clinical Trial Comparison Website
The C19early.com website tracks clinical trials. It is the best source of information on the studies of the effectiveness based upon clinical trials of different treatments for covid. However, it is more than this - as it is a model for how clinical trials should be communicated to the public so the extraordinarily corrupt medical establishment does not control the information. And it is the website that the medical establishment would like banned from the Internet.
One of the things the C19Early website showed was that early treatment significantly impacted the outcomes against covid.
The Benefit of Early Treatment
Notice that the earlier the treatment is used, the better the outcomes. Naturally, early treatment is measured in days with a respiratory disease like COVID-19, while in months with a disease like cancer. So the timings are different, but the principle is the same.
Even though this website does not track cancer clinical trials (unfortunately, no website does), the site holds essential observations. For one, a person's response to covid is like their response to cancer, greatly dependent upon the strength and health of their immune system.
Things like Zinc, Ivermectin, and Fenbendazole all empower the immune system and are, therefore, effective in the treatment and prevention of both COVID and cancer.
Offering Cancer Prevention as Well as Treatment
What is better than treatment is prevention. For anyone who is concerned with cancer prevention, both a very healthy lifestyle and diet, as well as things like Ivermectin and or Fenbendazole, are things that can be taken both as a treatment and as a preventative. We cover all these topics and the supporting specifics on our subscription website.
Impacts of Ivermectin on Cancer
The following are how Ivermectin works against cancer.
Impact #1: Inhibiting Proliferation of Tumor Cells
Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways.
The Ivermectin blocking of PAK1 proteins, aka activated kinase, is a reason for this.
The instrumentality of PAK1 in cancer growth is explained in the following quotation from the article Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations.
Impact #2: Inhibiting Metastasis
Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells.
Metastasis is how cancer spreads, and I cover this in detail in the article How Does Metastasis Work in the Body?
Impact #3: Promoting Apoptosis & Pyropoptsis
ivermectin promotes programmed cancer cell death, including apoptosis, autophagy, and pyropoptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Second, IVM seems to induce mixed cell death in tumor cells, which is also a controversial issue
A significant issue with the dysfunction of cancer is that the cancerous cells refuse instructions from the immune system to commit suicide -- or what is scientifically referred to as apoptosis. I cover apoptosis in the article How Ivermectin Improves Cancer Prevention and Treatment Through Improving Apoptosis or Programmed Cell Death.
Pyropoptosis is a type of apoptosis that is caused by inflammation.
Impact #4: Promoting Autophagy
Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells.
Autophagy clears away cells and recycles them. Different things can trigger more autophagy. I cover autophagy in the article Is Autophagy Effective Against Cancer?
Impact #5: Inhibit Cancer Cell Proliferation Through Inhibiting YAP1 Activity
Lung cancer has the highest morbidity and mortality among cancers. Nishio found that IVM could significantly inhibit the proliferation of H1299 lung cancer cells by inhibiting YAP1 activity.
Conclusion
There is ample evidence that Ivermectin is helpful against many different types of cancers. It is unlikely that these are the only cancers for which Ivermectin is effective, but the studies we have found so far show that Ivermectin works to combat and prevent it. Ivermectin is an immuno-modulator, so it has beneficial effects not only for cancer -- as one of the mechanisms of how Ivermectin works is improving the immune system, which means it improves the immune system against cancer and other diseases.
Regarding the dosage and sourcing of Ivermectin, see the article On the Topic of Ivermectin Dosage and Sourcing.
Why Are Anti-Parasitic Drugs Effective Against Cancer?
To understand why this class of drugs works against cancer, see the article The Mechanism of How Anti-Parasitic Drugs Work to Mitigate Cancer.
Our Recommended Source of Supply
- Our approved source for Ivermectin is Summit Products.
- They carry the Ivermectin we tested for bioequivalence
- (you can read about our testing here) for the active ingredient with the original Merck version but at a much lower price than the Merck version.
- This source makes Ivermectin much more accessible and has passed our testing.