The Testing Evidence for Using Ivermectin for Treating Melanoma or Skin Cancer
Last Updated on January 5, 2023 by Shaun Snapp
Executive Summary
- Ivermectin is proven to treat a variety of different cancers.
- Melanoma or skin cancer is one of them.
Introduction
In a previous article titled How Ivermectin Is Useful for Treating Cancer we covered the evidence for the benefits of Ivermectin for cancer. But the question of which cancers Ivermectin has been proven to be effective is a constant source of questions.
This article provides an overview coverage of these specific cancers.
There are a lot of quotes in this article, but I have a short one for each cancer type. The article uses the term “IVM” to mean Ivermectin
Cancer Type #9:Melanoma
Melanoma is the most common malignant skin tumor with a high mortality rate. Drugs targeting BRAF mutations such as vemurafenib, dabrafenib and PD-1 monoclonal antibodies, including pembrolizumab and nivolumab have greatly improved the prognosis of melanoma. Gallardo treated melanoma cells with IVM and found that it could effectively inhibit melanoma activity. Interestingly, IVM could also show activity against BRAF wild-type melanoma cells, and its combination with dapafinib could significantly increase antitumor activity. Additionally, it has been confirmed that PAK1 is the key target of IVM that mediates its anti-melanoma activity, and IVM can also significantly reduce the lung metastasis of melanoma in animal experiments. Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells. However, NAC reversed the effect of IVM, which indicated that IVM increased TFE3-dependent autophagy through the ROS signaling pathway.
This metanalysis study was published on the NIH or National Institutes of Health website. However, it was funded by Indian science institutes.
The Importance of The NIH Stopping Any Funding For Ivermectin Studies
Notice that none of the studies on Ivermectin were performed in the US. The US has by far the largest national medical research budget in the world, and so if the US is not performing studies, this is not only a negative but tells us something peculiar about what the NIH is deciding not to fund in the area of cancer research.
Zero is the number of studies funded by the NIH on Ivermectin. The NIH will not fund studies into generic drugs, as the NIH is controlled by pharmaceutical companies and they have deep financial ties to them. Funding research into generic drugs could end up showing those drugs as effective, which is a threat to pharmaceutical profits, which the NIH is dedicated to maximizing.
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Conclusion
There is now ample evidence that Ivermectin is useful against many different types of cancers. It is unlikely that these are the only cancers for which Ivermectin is effective, but the studies we were able to find so far show that Ivermectin works to combat and prevent it. Ivermectin is an immuno-modulator, so it has beneficial effects not only for cancer — as one of the mechanisms of how Ivermectin works are improving the immune system, which means it improves the immune system against cancer as well as other diseases.
Regarding dosage and sourcing of Ivermectin, see the article On the Topic of Ivermectin Dosage and Sourcing.
Why Are Anti Parasitic Drugs Effective Against Cancer?
If you are interested in understanding why this class of drugs works against cancer, see the article The Mechanism of How Anti Parasitic Drugs Work to Mitigate Cancer.
